HIGHLIGHTS
- who: August and colleagues from the Riphah International University, Pakistan Research Institute, United States have published the paper: The molecular pathogenesis of triptolide-induced hepatotoxicity, in the Journal: (JOURNAL) of 31/08/2019
- how: The result showed that continuous gavage of TP for 28 days could inhibit the activity and expression of CYP450 isoforms 3A 2C9 2C19 and 2E1 and cause hepatotoxicity in rats (Lu et_al 2017). The study identified the presence of autophagosomes by transmission electron microscopy and inhibition of autophagy decreased cell viability and enhanced apoptosis in a TP-induced HL7702 cytotoxicity model . . .
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