The mrna-binding protein ddx3 mediates tgf-β1 upregulation of translation and promotes pulmonary fibrosis

HIGHLIGHTS

• who: Wensheng Chen et al. from the DepartmentM University Station, Texas, USA have published the article: The mRNA-binding protein DDX3 mediates TGF-u03b21 upregulation of translation and promotes pulmonary fibrosis, in the Journal: (JOURNAL)
• what: In this paper and the previous work, the authors report a TGF-u03b21/DDX3/NEU3 /TGF-u03b21 positive feedback loop and show that inhibiting either DDX3 or NEU3 reduces lung fibrosis in bleomycin-treated mice.

SUMMARY

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with an average survival of 3-5 years . . .

 



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