The multi-omic landscape of primary breast tumors and their metastases: expanding the efficacy of actionable therapeutic targets

HIGHLIGHTS

• who: Guang Yang et al. from the School of Sciences, China Pharmaceutical University, Nanjing, China have published the research work: The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets, in the Journal: Genes 2022, 13, 1555. of 22/05/2022
• what: In genes that displayed significant somatic mutations, TCGA identified focal amplifications in EGFR, FOXA1, HER2 and PIK3CA; concurrently, this analysis showed focal deletions in MAP2K4, KMT2C (MLL3), PTEN and RB1 .
• how: A meta-analysis 6 of 25 of the TCGA BC expression data . . .
  

   

  

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