The n-terminal disease-associated r5l tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound tau patches

HIGHLIGHTS

• who: Alisa Cario from the Alisa Cario1, Sanjula PWickramasinghe2, Elizabeth Rhoades2, and Christopher L. Berger1, * From the Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA have published the article: The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches, in the Journal: (JOURNAL) of June/28,/2022
• what: The authors investigate the effect of the progressive supranuclear palsy- associated N-terminal R5L mutation on Tau-mediated microtubule dynamics using an in_vitro reconstituted system. The authors show that the R5L mutation does . . .
  

   

  

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