The neural signatures of psychoses in alzheimer’s disease: a neuroimaging genetics approach

HIGHLIGHTS

SUMMARY

    Carriers of the Apolipoprotein E (APOE) ε4 allele, i.e. the strongest genetic risk factor for sporadic late-onset AD, appear at higher risk of AD-related psychosis, although this finding has not been replicated by all studies. VBM regression analyses on the PE-PRS showed largely inconsistent positive associations with GM volume of cerebellar/occipital areas, at a conservative ­PT, in the whole sample and in the AD-PS group and with GM volume in the anterior cingulate in the HC group. No significant associations were detected in the AD-PS group, hence . . .

     

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