The non-obese diabetic mouse strain as a model to study cd8+ t cell function in relapsing and progressive multiple sclerosis

HIGHLIGHTS

  • who: Manu Rangachari from the Philipps-University, Germany have published the article: The non-obese diabetic mouse strain as a model to study CD8+ T cell function in relapsing and progressive multiple sclerosis, in the Journal: (JOURNAL)
  • what: Several decades` worth of evidence from animal models have supported the idea that CD4+ T_cells are the chief drivers of inflammation in MS. However, histopathological and clinical findings from human patients indicate that CD8+ T_cells are key players as well.

SUMMARY

    During MS, CD8+ T_cells upregulate cell adhesion molecules involved in immune trafficking . . .

     

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