HIGHLIGHTS
- who: Elena Porcù from the (UNIVERSITY) have published the paper: The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation, in the Journal: Scientific Reports Scientific Reports of 12/Dec/1987
- how: The authors investigated the antiangiogenic activity of TR-764 in HUVEC cells and its strong effect in_vivo as a vascular disrupting agent in the chick chorioallantoic membrane (CAM) and in a murine and human model of melanoma.
SUMMARY
It was selected among a series of benzothiophenes derivatives for its high antiproliferative activity in_vitro, being . . .
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