HIGHLIGHTS
- who: Vrouyr Bilemjian and collaborators from the Department of Hematology, University Medical Center Groningen, University of Groningen, GZ Groningen, The Netherlands have published the research: The Novel Immune Checkpoint GPR56 Is Expressed on Tumor-Infiltrating Lymphocytes and Selectively Upregulated upon TCR Signaling, in the Journal: (JOURNAL)
- what: Patients had given consent for the use of surgical material for research purposes. The authors identified that GPR56 mRNA expression was mostly detected in cytotoxic and/or (pre-)exhausted CD8 TILs. The authors identified that the G-protein Coupled Receptor (GPR56) appears to function as an immune-checkpoint . . .
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