HIGHLIGHTS
- who: Tomoya Sakamoto from the Cardiovascular Instituteat the University of Pennsylvania, Philadelphia, PA, USA have published the research: The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: To further probe the cooperativity of ERRu03b3 and GATA4 on a shared target gene, the authors focused on TNNI3, an adult cardiac sarcomeric gene isoform and known cardiac maturation marker in human cardiac myocytes38. This observation set the stage for the studies described herein aimed at understanding how the nuclear receptor ERR coordinately regulates canonical . . .
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