HIGHLIGHTS
- who: . and colleagues from the University of California, Davis, United States have published the research work: The paradigm shift: Heartbeat initiation without the pacemaker, in the Journal: (JOURNAL)
- what: In some dormant cells Ca releases can be noisy and dysrhythmic (Kim et_al, 2018; Grainger et_al, 2021), i.e., not that large and rhythmic as in the model . The authors demonstrate for the first time that rhythmic cardiac pacemaker impulses can be generated by an ensemble of heterogeneous (specialized) dormant SAN cells, i.e., cells lacking intrinsic automaticity.
- how: The authors simulated each cell . . .
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