The pathogenesis of diabetes

HIGHLIGHTS

  • who: Huiqin Guo and collaborators from the Institute of Biotechnology, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, China have published the article: The Pathogenesis of Diabetes, in the Journal: (JOURNAL)

SUMMARY

    People with diabetes usually exhibit four metabolic abnormalities: abnormal insulin action, insulin secretion dysfunction, increased endogenous glucose output, and obesity. Lekva et_al showed that high glucose activated toll-like receptor 4 (TLR4) and promoted the expression of pro-inflammatory factors, which, in turn, enhanced insulin resistance. High levels of tumor necrosis factor-α (TNF . . .

     

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