The pathological g51d mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity

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  • who: Catherine K. Xu and colleagues from the Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge , EW, UK have published the research: The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity, in the Journal: Molecules 2022, 1293 of /2022/
  • what: Deconvolution of CD spectra of WT oligomers suggests that they contain around 11% of u03b1-helical structure, which was not detected by solid-state NMR analysis , indicating that the percentage of u03b1-helical content the authors report here should only be used as a relative quantification . . .

     

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