The phosphatidylinositol-transfer protein nir3 promotes pi(4,5)p2 replenishment in response to tcr signaling during t cell development and survival

HIGHLIGHTS

• who: Wen Lu from the (UNIVERSITY) have published the research work: The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival, in the Journal: (JOURNAL) of 16/03/2022
• what: The authors show that a PI transfer protein (PITP), Nir3 (Pitpnm2), promotes PIP2 replenishment following TCR stimulation and is important for T_cell development.
• how: To investigate the evolutionary history of these two proteins the authors identified orthologs across multiple animal lineages and developed a phylogenetic reconstruction analysis.

SUMMARY

 



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