The phosphodiesterase inhibitor tadalafil promotes splenic retention of plasmodium falciparum gametocytes in humanized mice

HIGHLIGHTS

  • who: Daniela Barbieri from the CNRS, Centre d`Immunologie et des Maladies Infectieuses, Paris, France, Service de Parasitologie-Mycologie Assistance Universidade de Lisboa, Portugal have published the article: The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice, in the Journal: (JOURNAL)
  • what: The authors used flow cytometry, bioluminescence imaging and RT-qPCR analyses to follow the kinetics of P. falciparum GIE in the blood circulation of this humanized mouse model over a short or a long period of time to quantify the effect of tadalafil on GIE persistence in the . . .

     

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