HIGHLIGHTS
- who: Janik B. Hedderich from the University Marburg of Medicine, Stanford, CA, USA have published the Article: The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Through mutations of two pockets that have not been targeted by a synthetic ligand before, the authors demonstrate that the residues forming these pockets are indeed involved in receptor activation after stimulation with an orthosteric agonist. Last, but not least, the authors compare the sequence similarity of the most frequently occurring pockets, thereby providing a quantitative assessment of . . .
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