HIGHLIGHTS
- who: DNA damage and collaborators from the Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy have published the Article: The POU-Domain Transcription Factor Oct-6/POU3F1 as Regulator of Cellular Response to Genotoxic Stress, in the Journal: (JOURNAL)
- what: The authors provide evidence that Oct-6 may play a role in the regulation of cellular response to damaging agents. By using the shRNA approach the authors demonstrate that in doxorubicin-treated H460 non-small-cell lung carcinoma (NSCLC) cells Oct-6 depletion leads to a reduced G2-cell cycle arrest and senescence . . .
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