The primary familial brain calcification-associated protein myorg is an α-galactosidase with restricted substrate specificity

HIGHLIGHTS

• who: Richard W. Meek et al. from the Department of ChemistryUniversity of York, York, United Kingdom, Department of Molecular Biology have published the article: The primary familial brain calcification-associated protein MYORG is an u03b1-galactosidase with restricted substrate specificity, in the Journal: (JOURNAL) of April/28,/2022
• what: The authors show that MYORG is an u03b1-galactosidase and present the high-resolution crystal structure of MYORG in complex with substrate and inhibitor. The authors demonstrate that MYORG, enigmatically, functions not as an u03b1-glucosidase but rather an u03b1-galactosidase and shows marked preference for . . .
  

   

  

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