HIGHLIGHTS
SUMMARY
Numerous studies have shown that ovarian aging is strongly associated with the risk of breast cancer, but its prognostic impact on breast cancer is not yet fully understood. Menarche and menopause mark the origin and end points in the process of ovarian ageing, as well as affect breast cancer risk. It has been well-documented that women who experienced menarche at an early age have an exponentially increased risk of developing breast cancer. A comprehensive understanding of the relationship between the expression of the 290 ovarian aging-related genes (OARGs) and survival outcomes in . . .
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