The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis

HIGHLIGHTS

• who: Xin Jin from the (UNIVERSITY) have published the paper: The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis, in the Journal: (JOURNAL) of February/10,/2020
• what: The authors show that exposure of three different human cancer cell lines to FLZ increases the phosphorylation of key translation factors, particularly of initiation factor 2 (eIF2) and elongation_factor 2 (eEF2), modifications that inhibit their activities. The authors show that FLZ induces cancer cell death and that this effect involves contributions from the phosphorylation of both eEF2 and eIF2. The . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.