The proinflammatory cytokine tnfα induces dna demethylation⠍dependent and ⠍independent activation of interleukin-32 expression

HIGHLIGHTS

• who: Zuodong Zhao from the (UNIVERSITY) have published the research work: The proinflammatory cytokine TNFα induces DNA demethylation⠍dependent and ⠍independent activation of interleukin-32 expression, in the Journal: (JOURNAL) of October/17,/2018
• what: The authors show that IL-32 is repressed by DNA methylation in HEK293 cells.
• how: These results indicated that long-term TNF␣ treatment not only caused a stable epigenetic change but also led to a sustained change in basal expression of the IL-32 gene. RT-qPCR results showed that the up-regulation of IL-32 was maintained . . .
  

   

  

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