HIGHLIGHTS
- who: Dirk Eulberg and collaborators from the University of Florida, United States have published the research: The prospect of tumor microenvironment-modulating therapeutical strategies, in the Journal: (JOURNAL)
SUMMARY
Exemplary strategies include (i) monoclonal_antibodies (mAbs) directed at tumor-associated antigens and markers (e_g, human epidermal growth factor receptor 2 and CD20); (ii) stimulation of effector leukocytes by means of immune checkpoint inhibitors (ICIs); and_(iii) adoptive cell transfer of genetically engineered immune cells (e_g, chimeric antigen receptor T_cells; CAR-T_cells). A major mechanism by which an immunosuppressive TME is established is the upregulated . . .
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