The pulmonary microvascular endothelial barrier function is controlled by the pge -ep signaling axis

HIGHLIGHTS

• who: Ku00f3nya et_al BMC Pharmacology and colleagues from the Our data support the hypothesis that endothelial cells, as gate-keepers of the vessel wall can actively participate in the inflammatory processWe have shown that PGE2, via activating , receptors, enhances the barrier function of the endothelium by protecting the endothelial adherent junctional network and preventing leukocyte diapedesis. Therefore, agonists might be promising new therapeutic tools in treating inflammatory diseases. Author details , Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. Published: , November , have . . .
  

   

  

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