HIGHLIGHTS
SUMMARY
Mood disturbances are an important factor determining QOL in both the mental (Papuć and Stelmasiak, 2012; Barzegar et_al, 2018) and the general domain for MS patients (Berrigan et_al, 2016; Boogar et_al, 2017). Globally, 2.8 million people suffer from MS; however, its occurrence depends on latitude (Logroscino et_al, 2018; Walton et_al, 2020). One of the most common is depression (Boeschoten et_al, 2017; Henry et_al, 2019), a mood disorder that causes persistent sadness and loss of interest. The global prevalence of depression has been still increasing, especially during the COVID-19 pandemic (Vos et_al, 2016 . . .
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