HIGHLIGHTS
- who: Michaela Poliaková from the (UNIVERSITY) have published the article: The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer, in the Journal: (JOURNAL)
- what: In the already mentioned study focusing on imatinibtreated BCR-ABL-positive cells, the increase of mitochondrial glucose metabolism following treatment by high imatinib concentration (above the IC50 value of 2.5 μmol/L) was accompanied by a higher energy state (e_g, with an increase of all phosphate nucleoside triphosphates (NTPs)), being possibly a result of an activation of the TCA cycle together with dysregulation of glucose metabolism . The . . .
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