HIGHLIGHTS
- who: Saroor A. Patel from the (UNIVERSITY) have published the article: The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer, in the Journal: (JOURNAL) of 11/02/2021
- what: Using experimental models, functional genomics and analyses of patient samples, the authors demonstrate that the lineage transcription factor paired box 8 (PAX8) is required for oncogenic signalling by two common genetic alterations that cause clear cell renal cell carcinoma (ccRCC) in humans: the germline variant rs7948643 at 11q13.3 and somatic inactivation of the von Hippel-Lindau tumour suppressor (VHL)4-6. The authors . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.