The rna-binding protein fus/tls interacts with spo11 and prdm9 and localize at meiotic recombination hotspots

HIGHLIGHTS

• who: Teresa Giannattasio from the University of Rome u201cTor Vergatau201d, Section of Anatomy, Via Montpellier, , Rome, Italy have published the article: The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots, in the Journal: (JOURNAL)
• what: The authors demonstrate that FUS/TLS partially colocalizes with PRDM9 on the meiotic chromosome axes marked by the synaptonemal complex component SYCP3 and physically interacts with PRDM9. The authors show that FUS/TLS also interacts with one of the axis-bound SPO11auxiliary factors essential for DSB formation. Using chromatin immunoprecipitation experiments the . . .
  

   

  

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