The rna-binding protein hur is a novel target of pirh2 e3 ubiquitin ligase

HIGHLIGHTS

• who: Alexandra Daks from the (UNIVERSITY) have published the paper: The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase, in the Journal: (JOURNAL)
• what: Among those, the authors focused on the RNA-binding protein, HuR (ELAVL1), because the latter has previously been reported to participate in the p53 regulation. In line with this observation, in this study the authors showed that Pirh2 regulated c-Myc via affecting the stability of HuR by ubiquitinating the latter. To corroborate the results , the authors propose a model (Fig 7E), whereby Pirh2 attenuates the . . .
  

   

  

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