The rna-binding protein qki governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes

HIGHLIGHTS

• who: Pablo Montau00f1u00e9s-Agudo and collaborators from the Department of Experimental Cardiology, University of, Meibergdreef, AZ, The have published the research: The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes, in the Journal: (JOURNAL) of 13/05/2022
• what: The authors aim to identify the in vivo function of QKI in the adult mouse heart. The authors show that QKI depletion in the adult myocardium leads to a DCM that rapidly progresses into heart failure and provide evidence that disrupted sarcomeric organization underlies this contractile . . .
  

   

  

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