The role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons

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SUMMARY

    Two enzymes are involved in these reactions: tubulin tyrosine carboxypeptidase (Aillaud et_al, 2017; Nieuwenhuis et_al, 2017) and tubulin tyrosine ligase (TTL) (Barra et_al, 1988), respectively. Dynamic MTs frequently invade dendritic spines and are important for spinogenesis, synaptic targeting of NMDA receptors, and even synaptic plasticity (Gu et_al, 2008; Kapitein et_al, 2011; Martel et_al, 2016). Consistent with these findings, the transient accumulation of dynamic MTs in hippocampal dendritic spines is necessary for learning and memory processes in contextual fear conditioning, NMDAdependent memory tasks, and memory discrimination tasks (Uchida et_al, 2014; Martel et_al, 2016). Slice cultures . . .

     

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