The role of androgens in pressure overload myocardial hypertrophy

HIGHLIGHTS

  • who: Marie Schafstedde and Sarah Nordmeyer from the Medicine (HZ), Germany Laval University, Canada have published the paper: The role of androgens in pressure overload myocardial hypertrophy, in the Journal: (JOURNAL)
  • what: Testosterone and/or its active metabolite DHT increase the hypertrophic response of left ventricular myocardium to pressure overload in animal models and associations were seen in human subjects.
  • how: In the study cohort a very small number of four male patients happened to be on anti-androgenic therapy due to concomitant prostate disease (two patients were treated with GnRH analogues showing . . .

     

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