The role of cdk8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis

HIGHLIGHTS

  • who: Takanori Yamada from the Pharmaceutical University, Gifu, Japan have published the article: The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis, in the Journal: (JOURNAL) of July/12,/2022

SUMMARY

    Osteoporosis leads to increased bone fragility and risk of bone fractures, which are often associated with morbidity, prolonged hospitalization, and increased public health burden (Cauley, 2013; Manolagas and Parfitt, 2010; Rachner et_al, 2011). Osteoblasts and osteoclasts are finely coupled to maintain proper bone mass, quality, and strength in the young or healthy bone marrow microenvironment, whereas their . . .

     

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