HIGHLIGHTS
- who: Shuntaro Morikawa and Fumihiko Urano from the Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, StLouis, MO, USA have published the Article: The Role of ER Stress in Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome, in the Journal: (JOURNAL)
- what: Excess ER stress in pancreatic u03b2-cells is involved in the pathogenesis of T2DM, and dysfunction of multiple UPR-related genes, including WFS1, are candidate genetic risk factors for T2DM.
SUMMARY
Dysregulation of ER homeostasis underlies pancreatic β-cell dysfunction in type 1 diabetes . . .
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