HIGHLIGHTS
- who: HSP and collaborators from the University of Bremen, Germany have published the research: The role of heat shock proteins in preventing amyloid toxicity, in the Journal: (JOURNAL)
- what: HSP70 exposes ends of substrates on which HSP100 can subsequently pull, increases the activity of HSP100 and binds the newly disaggregated proteins. frontiersin.org 10.3389/fmolb.2022.1045616 Although the disaggregation activity of Hsp100 would make it a useful medical target for amyloid disaggregation, structural/ mechanistic studies which focused on Hsp100s effect on amyloid aggregates are few and far between.
- future: For other . . .
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