The role of inflammation in hematopoiesis and bone marrow failure: what can we learn from mouse models?

HIGHLIGHTS

  • who: Jun Wang from the Medical University of Graz, Austria have published the research work: The role of inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models?, in the Journal: (JOURNAL)
  • future: Work has also shown that IFNa/b is required for the increase of IL-18 expression during infection processes leading to loss of short-term HSCs.

SUMMARY

    The hematopoietic homeostasis relies on the division and self-renewing of the hematopoietic stem_cells (HSCs), with enormous self-renewal capacities, that differentiate through the lineage-committed progenitors . . .

     

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