The role of lfa-1 for the differentiation and function of regulatory t cells—lessons learned from different transgenic mouse models

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  • who: Tanja Klaus and colleagues from the Department of Dermatology, University Medical Center Mainz, Mainz, Germany have published the research: The Role of LFA-1 for the Differentiation and Function of Regulatory T Cellsu2014Lessons Learned from Different Transgenic Mouse Models, in the Journal: (JOURNAL)
  • what: Since a constitutive knockout affects all leukocytes and may limit the validity of studies focusing on their cell type-specific role the authors established a Treg-specific CD18-floxed mouse strain. In the following chapter the authors compare the characteristics of the u03b22 -integrindeficient mouse models, focusing on the clinical . . .

     

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