HIGHLIGHTS
- who: Jiahao Zhao from the University, China have published the article: The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases, in the Journal: (JOURNAL)
- what: The main reason is that the knockdown of MFN2 leads to reduced junctions and reduced ROS production in mitochondria and the ER .
- how: The experimental results indicated that the NLRP3 activator cannot induce the IL-1u03b2 generation and CASPASE-1 activation in VDAC-deficient cells.
- future: ROS production is reduced after overexpression of MFN2 in other studies however more work is . . .
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