The role of negatively charged lipids in lysosomal phospholipase a2 function

HIGHLIGHTS

• who: Akira Abe from the Department University of have published the research: The role of negatively charged lipids in lysosomal phospholipase A2 function, in the Journal: (JOURNAL) of March/25,/2009
• what: The authors have demonstrated that several anionic phospholipids markedly enhance LPLA2 activity toward a zwitterionic phospholipid (Fig 1). Recombinant mouse LPLA2 used in this study showed a pH optimum of about 4.5 when the liposomes containing sulfatide were used as a substrate. This study shows that LPLA2 shares some common properties with the type IIA secreted phospholipase A2 with respect to interfacial . . .
  

   

  

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