The role of nlrp3 inflammasome in psychotropic drug-induced hepatotoxicity

HIGHLIGHTS

• who: Wenqing Mu from the (UNIVERSITY) have published the research work: The role of NLRP3 inflammasome in psychotropic drug-induced hepatotoxicity, in the Journal: (JOURNAL) of 26/04/2022
• what: The studies demonstrate that fluoxetine and other psychotropic drugs with similar effects can act as exogenous DAMPs directly trigger the NLRP3 inflammasome activation accompanied by caspase-1 activation, IL-1u03b2 secretion and GSDMD mediated pyroptosis.
• how: The results indicated that the Cell Death Discovery 8313 production of caspase-1 and IL-u03b2 and cleavage of GSDMD were triggered by fluoxetine in a dose . . .
  

   

  

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