The role of p16 gene and p16ink4a protein in hematologic malignancies and therapeutic implications: a systematic review

HIGHLIGHTS

• What: This systematic review aims to elucidate the multifaceted roles of the gene and P16INK4A protein in hematological malignancies focusing on their impact on disease pathogenesis prognostic significance and therapeutic implications. comprehensive search was conducted across electronic databases including PubMed Scopus and Google Scholar using predefined search terms related to P16INK4A hematological malignancies and therapy. The aim of this systematic review was to present an overview of the existing knowledge on the function of the p16INK4a gene and P16INK4a protein in the development of hematological malignancies. The review aimed to investigate the p16 gene and P16INK4a protein . . .
  

   

  

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