The role of p53 deacetylation in p21waf1 regulation by laminar flow*

HIGHLIGHTS

• who: Lingfang Zeng from the Physiological levels of laminar flow not only arrest the EC cell cycle and increase vessel relaxation but also prevent apoptosis of ECs in response to a variety of stimuli, including tumor necrosis factor-␣, oxidized low density lipoprotein, and angiotensin II (20, )Hence, another possible functional consequence of the p Waf, up-regulation by the deacetylated p, is to protect ECs from apoptosis. This possibility is supported by the finding that TSA inhibition of HDAC induces the apoptosis of several cell types such as Huh, hepatoma cells and , gastric carcinoma cells (26, ). In . . .
  

   

  

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