HIGHLIGHTS
SUMMARY
Reproductive aging is a process that begins in women at their mid-to-late 30s, characterized by a gradual decline in ovarian function, the number of estrogen-secreting growing follicles, and oocytes` quantity and quality. The authors have previously characterized the role of PEDF in the ovary, and have shown that the GCs of both rodents and humans produce and secrete PEDF in a hormonally-dependent manner, inversely to the upregulation of vascular endothelial growth factor (VEGF); estradiol, luteinizing hormone (LH), and progesterone downregulate the GCs` PEDF expression and secretion. The work examines the . . .
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