The role of ppar γ in the cyclooxygenase pathway in lung cancer

HIGHLIGHTS

• who: Saswati Hazra et al. from the Division of Medicine at UCLA, Los Angeles, CA, USA have published the research: The Role of PPAR u03b3 in the Cyclooxygenase Pathway in Lung Cancer, in the Journal: (JOURNAL)
• what: To define the mechanism underlying COX-2 independent suppression of PGE2 production, the authors focused on the prostaglandin synthases that are responsible for the PGE2 production and on 15PGDH the catabolic enzyme responsible for its degradation to biologically inactive15-keto derivatives .
• future: More research is required to define opportunities to specifically interfere with PGE2 production metabolism . . .
  

   

  

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