HIGHLIGHTS
- who: April and collaborators from the University of Cambridge, United Kingdom have published the Article: The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis, in the Journal: (JOURNAL)
- what: The authors investigated how PAD4-mediated NETs control intestinal mucosal injury in DSS-induced acute and chronic colitis using PAD4 knockout (PAD4-/-) mice and Clamidine administered wide-type mice. The authors observed that DSS-induced colitis was characterized by excessive inflammatory indicators, such as the upregulation of proinflammatory cytokines (IL-17, IL-6, IL-1b) in the colon and prevailing . . .
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