The role of pten in epithelial-mesenchymal transition

HIGHLIGHTS

  • who: Olga Fedorova et al. from the (UNIVERSITY) have published the research work: The Role of PTEN in Epithelial-Mesenchymal Transition, in the Journal: Cancers 2022, 3786 of /2022/
  • what: In this study, the link between AKT/PTEN/SMAD3 in response to TGF-β was demonstrated .

SUMMARY

    In this review the authors discuss the role of PTEN in metastasis, including crosstalk between the signaling networks of PTEN and EMT, which ultimately affects the gene_expression programs of cellular plasticity and metastasis. β-arrestin is an important regulator of the lipid-phosphatase activity of PTEN . . .

     

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