HIGHLIGHTS
- who: Aster Legesse from the Open University have published the Article: The role of RNF149 in the pre-emptive quality control substrate ubiquitination, in the Journal: (JOURNAL) of 23/Dec/2021
- how: Next the authors evaluated the E3 ligase activity of RNF149 by means of an in-vitro ubiquitination assay (Fig 1C) that confirmed E2 dependency as well as RING domain functionality as a predicted RING mutant abolished this activity.
- future: Future investigation into the molecular events governing this regulation and the role of the PA luminal domain that governs this __NEWPAGE__ARTICLE control . . .
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