HIGHLIGHTS
- who: Barbara Tedesco et al. from the Via Balzaretti, Milan, Italy have published the research work: The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases, in the Journal: (JOURNAL)
- what: Int.
SUMMARY
In such cases, it may be feasible to differentiate between MNDs with loss of function (LOF) mutations, in which the protein encoded by the mutated gene has lost one of its normal functions, and MNDs with gain of function (GOF) mutations, in which the encoded protein has acquired a novel and potentially neurotoxic activity. Proteotoxicity . . .
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