The role of the bmp signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis

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  • who: Metastasis et al. from the Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland have published the article: The Role of the BMP Signaling Antagonist Noggin in the Development of Prostate Cancer Osteolytic Bone Metastasis, in the Journal: (JOURNAL) of January/13,/2011
  • what: This investigation provides new evidence for a model of osteolytic bone where constitutive secretion of noggin by cancer cells mediates inhibition of bone formation thereby preventing repair of osteolytic lesions generated by an excess of osteoclast-mediated bone resorption. The authors show for . . .

     

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