The salmonella effector sted mediates march8-dependent ubiquitination of mhc ii molecules and inhibits t cell activation

HIGHLIGHTS

• who: Ethel Bayer-Santos from the Centre London, Armstrong Road, London , AZ, UK Cook University have published the research work: The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation, in the Journal: (JOURNAL)
• what: The authors propose that SteD is an adaptor forcing inappropriate ubiquitination of mMHCII by and thereby suppressing T cell activation. The authors show that SteD is a SPI-2 T3SS effector that is required and sufficient for depletion of mMHCII from the surface of infected cells. The authors show here the existence of . . .
  

   

  

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