The senescence-associated secretome of hedgehog-deficient hepatocytes drives masld progression

HIGHLIGHTS

• What: The authors aimed to determine whether secretomes of Smo-deficient hepatocytes perpetuate to drive RNASeq analysis of liver samples from human and murine cohorts with confirmed that hepatocyte populations in livers were depleted of Smo+ cells and enriched with senescent cells. The authors evaluated the hypothesis that the secretome of Hedgehog-deficient hepatocytes perpetuates senescence to drive MASLD progression. The authors affirm that the research with human samples was conducted in accordance with the Declarations of Helsinki and Istanbul and approved by the Duke University Health System (DUHS) IRB (Pro00005368), with written consent given by all . . .
  

   

  

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