The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

HIGHLIGHTS

• who: Manikam S. Saravanan from the Utrecht University Center Utrecht, CX, Utrecht, The Netherlands have published the research: The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers, in the Journal: Scientific Reports Scientific Reports
• what: The authors investigated the interaction between hIAPP and the small-molecule inhibitor anle145c. Rather surprisingly, the results in this study show that anle145c is perhaps the most effective inhibitor for hIAPP fibril formation reported thus far.
• how: For this initial study the authors selected the DPP-derived small-molecule . . .
  

   

  

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